COPROCESSED EXCIPIENTS PDF

Co-processed excipients have been developed to handle changes in the physical properties of particles at sub-particle levels. By co-processing two excipients. A co-processed excipient is any combination of 2 or more excipients obtained by physical co-processing that does not lead to the formation of. co-processed excipients ppt. 1. 1; 2. CO-PROCESSED Presented by- Under the guidance ofMr. Bhaskar N. Bangar Dr. N. H. Aloorkar.

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Co-processed excipients were prepared to improve the process ability and efficacy of commonly used excipients and to impart multi-functional qualities to the excipients and hence that the tablets with the desired attributes can be produced. Preparation of mouth dissolving tablet As given in Table 5, Terbutaline sulphate and coprocessed superdisintegrant were individually weighed and mixed thoroughly for about 5 min.

Isolation of mucilage from Ocimum bascilium: The angle of repose was found to be Preparation of coprocessed superdisintegrant A blend of Mannitol- Mucilage was added to 65 ml of isopropyl alcohol in different concentrations.

It was evaluated for different flow properties and disintegration time. To overcome these problems, the functionality of excipients can be improved by either developing new grades of excipients or modification of existing excipients.

After 30 days the samples were withdrawn and characterized for weight variation, hardness, disintegration time, drug content and in vitro drug release study. Hand Book of Pharmaceutical Excipients; pp. Characterization of mucilage The mucilage which was isolated from the seeds of Ocimum bascilium was evaluated for flow properties, Loss on drying and swelling index.

Particle level comprises individual particle properties such as shape, size, surface area, and porosity that reflect in bulk level by improving functionality excipients [ 6 ]. Both excipients should be in such a proportion that the formed blend shows good binding properties and good flow properties.

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A known volume of powder was placed in a graduated cylinder and consider as initial volume. The friabilator was rotated for 4 min or revolutions.

Co-processed Excipients

In addition, Mannitol is non-hygroscopic and may thus be used with moisture-sensitive ingredients. The optimized excipienfs did not show any significant change in drug content when kept at different conditions and periods. Natural material Ocimum bascilium due to its high swelling capacity disintegrate the tablet very fast. They are highly safe, stable, biocompatible, cheap, easily available, chemically inert, nontoxic and biodegradable in nature [ 7 ]. The results are depicted in Table 6.

However, the numbers of excipients that can actually fulfill such performance requirements are limited. The natural mucilage has been explored as super disintegrants due to its high swelling property. Mannitol and coprocesswd stearate were blended with the above mixture for about 2 min.

Excipiebts coprocessed excipients were compressed into tablet form at different concentrations 2. Arch Pharm Res All results were within the given limits. The evaluation was carried out as described in the Pharmacopoeia [ 12 ].

Both excipients have very poor flow properties. Methods Isolation of mucilage from Ocimum bascilium: The composition of the tablets was represented in Table 1. The aim of this technique is to improve the flow properties of the used excipients when compared to dxcipients with the individual physical mixtures. As given in Table 5, Terbutaline sulphate and coprocessed superdisintegrant were individually weighed and mixed thoroughly for about 5 min.

The powdered mucilage was stored in desiccator until further use.

The tablet was put in the beaker and whole assembly was gently stirred, the time for the tablet to completely disintegrate into fine particles was noted [ 16 ]. The selected concentration of coprocessed mucilage was used in the preparation of mouth dissolving tablet.

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Formulation and Evaluation of Coprocessed Excipient for Mouth Dissolving Formulation

Direct compression is highly influenced by powder characteristics such as flow ability, compressibility and dilution potential.

Select your excipienys of interest to view the total content in your interested language. Developed tablets were evaluated for usual tablet tests such as weight variation, hardness, friability, drug content. The material was squeezed out using muslin cloth to remove the mark from the seeds.

Several bulk powder characteristics have been employed clprocessed indirect estimation of the degree of powder flow. A total of 3 g of granules were weighed and transferred to a measuring cylinder.

The blends containing the drug and co-processed excipients were formulated into a tablet by direct compression method. This indicates that there is no interaction between drug and polymer used in the formulation i. The drug was extracted with methanol, filtered and the volume was made up to the volume using 6. This blend was mixed well and was compressed in a rotary tablet machine using 5 mm punch die. It has excellent swelling index that is Atorvastatin calcium shows pH dependent solubility and is soluble in alkaline medium.

Evaluation of mouth dissolving tablets Developed tablets were evaluated for usual tablet tests such as weight variation, hardness, ecipients, drug content.